Traumatic Brain Injury-Associated Coagulopathy
نویسندگان
چکیده
منابع مشابه
Coagulopathy after Traumatic Brain Injury
Copyright: © 2012 Alexiou GA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Traumatic brain injury (TBI) is a major public health problem, leading to a considerable number of deaths and disability mainly amo...
متن کاملCardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice.
Cardiolipin (CL) is an anionic phospholipid located exclusively in the mitochondrial inner membrane. Its presence in blood indicates mitochondrial damage and release from injured cells. Here, we report the detection of CL-exposed brain-derived mitochondrial microparticles (mtMPs) at 17 547 ± 2677/μL in the peripheral blood of mice subjected to fluid percussion injury to the brain. These mtMPs a...
متن کاملSympathoadrenal Activation is Associated with Acute Traumatic Coagulopathy and Endotheliopathy in Isolated Brain Injury
BACKGROUND Acute coagulopathy after traumatic brain injury (TBI) involves a complex multifactorial hemostatic response that is poorly characterized. OBJECTIVES To examine early posttraumatic alterations in coagulofibrinolytic, endothelial, and inflammatory blood biomarkers in relation to sympathetic nervous system (SNS) activation and 6-month patient outcomes, using multivariate partial least...
متن کاملRelationship between trauma-induced coagulopathy and progressive hemorrhagic injury in patients with traumatic brain injury
Progressive hemorrhagic injury (PHI) can be divided into coagulopathy-related PHI and normal coagu- lation PHI. Coagulation disorders after traumatic brain injuries can be included in trauma-induced coagulopathy (TIC). Some studies showed that TIC is associated with PHI and increases the rates of disability and mortality. In this review, we discussed some mechanisms in TIC, which is of great im...
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ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2012
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2012.2348